Body size and intracranial volume interact with the structure of the central nervous system: A multi-center in vivo neuroimaging study

作者：René Labounek, Monica T. Bondy, Amy Paulson, Sandrine Bédard, Mihael Abramovic, Eva Alonso‐Ortiz, Nicole Atcheson, Laura Barlow, Robert Barry, Markus Barth, Marco Battiston, Christian Büchel, Matthew D. Budde, Virginie Callot, Anna Combes, Benjamin De Leener, Maxime Descoteaux, Paulo Loureiro de Sousa, Marek Dostál, Julien Doyon, Adam Dvorak, Falk Eippert, Karla R. Epperson, Kevin Epperson, Patrick Freund, Jürgen Finsterbusch, Alexandru Foias, Michela Fratini, Issei Fukunaga, Claudia A. M. Gandini Wheeler‐Kingshott, Giancarlo Germani, Guillaume Gilbert, Federico Giove, Francesco Grussu, Akifumi Hagiwara, Pierre‐Gilles Henry, Tomáš Horák, Masaaki Hori, James M. Joers, Kouhei Kamiya, Haleh Karbasforoushan, Miloš Keřkovský, Ali Khatibi, Joo-won Kim, Nawal Kinany, Hagen H. Kitzler, Shannon Kolind, Yazhuo Kong, Petr Kudlička, Paul Kuntke, Nyoman D. Kurniawan, Sławomir Kuśmia, Maria Marcella Laganà, Cornelia Laule, Christine Law, Tobias Leutritz, Yaou Liu, Sara Llufriú, Sean Mackey, Allan R. Martin, Eloy Martínez‐Heras, Loan Mattera, Kristin P. O’Grady, Nico Papinutto, Daniel S. Papp, Deborah Pareto, Todd B. Parrish, Anna Pichiecchio, Ferrán Prados, Àlex Rovira, Marc J. Ruitenberg, Rebecca S. Samson, Giovanni Savini, Maryam Seif, Alan C. Seifert, Alex K. Smith, Seth A. Smith, Zachary A. Smith, Elisabeth Solana, Yuichi Suzuki, George Tackley, Alexandra Tinnermann, Jan Valošek, Dimitri Van De Ville, Marios Yiannakas, Kenneth A. Weber, Nikolaus Weiskopf, Richard G. Wise, Patrik O. Wyss, Junqian Xu, Julien Cohen‐Adad, Christophe Lenglet, Igor Nestrašil · 发表于：Imaging Neuroscience · 年份：2025 · DOI：10.1162/imag_a_00559 · 被引用次数：7 · 研究领域：Advanced Neuroimaging Techniques and Applications、Functional Brain Connectivity Studies、Traumatic Brain Injury and Neurovascular Disturbances

Clinical research emphasizes the implementation of rigorous and reproducible study designs that rely on between-group matching or controlling for sources of biological variation such as subject's sex and age. However, corrections for body size (i.e., height and weight) are mostly lacking in clinical neuroimaging designs. This study investigates the importance of body size parameters in their relationship with spinal cord (SC) and brain magnetic resonance imaging (MRI) metrics. Data were derived from a cosmopolitan population of 267 healthy human adults (age 30.1 ± 6.6 years old, 125 females). We show that body height correlates with brain gray matter (GM) volume, cortical GM volume, total cerebellar volume, brainstem volume, and cross-sectional area (CSA) of cervical SC white matter (CSA-WM; 0.44 ≤ r ≤ 0.62). Intracranial volume (ICV) correlates with body height (r = 0.46) and the brain volumes and CSA-WM (0.37 ≤ r ≤ 0.77). In comparison, age correlates with cortical GM volume, precentral GM volume, and cortical thickness (-0.21 ≥ r ≥ -0.27). Body weight correlates with magnetization transfer ratio in the SC WM, dorsal columns, and lateral corticospinal tracts (-0.20 ≥ r ≥ -0.23). Body weight further correlates with the mean diffusivity derived from diffusion tensor imaging (DTI) in SC WM (r = -0.20) and dorsal columns (-0.21), but only in males. CSA-WM correlates with brain volumes (0.39 ≤ r ≤ 0.64), and with precentral gyrus thickness and DTI-based fractional anisotropy in ...