Synergistic Photothermal and Photodynamic Therapy against Bacterial Infections Using Carbon Quantum Dots Modified Molybdenum Disulfide

作者：Yayu Chen, Pengcheng Huang, Wenting Hong, Wanqing Xu, Xiaoping Chen, Shuxian Li, C. Liu, Yuansheng Wang, Xiaoyan Zhang, Yuqiong Wu, Fangchuan Chen · 发表于：ACS Applied Nano Materials · 年份：2025 · DOI：10.1021/acsanm.5c01491 · 被引用次数：4 · 研究领域：Nanoplatforms for cancer theranostics、Carbon and Quantum Dots Applications、Advanced Nanomaterials in Catalysis

Oral and maxillofacial infections are primarily caused by pyogenic bacterial infections, with common pathogens including Staphylococcus aureus and Escherichia coli . In this study, we developed a nonantibiotic antibacterial material, carbon quantum dots (CQDs) modified molybdenum disulfide (MoS 2 ), through a well-designed fabrication process. CQDs were used as highly efficient cocatalysts to enhance the near-infrared absorption capacity of the composite. Under near-infrared light (NIR) irradiation (1.5 W/cm 2 for 5 min), the 18.75% CQDs/MoS 2 composite, with CQDs concentration reaching 18.75%, exhibited complete antibacterial activity, demonstrating 100% efficacy against both S. aureus and E. coli . In addition, under NIR irradiation, the obtained CQDs/MoS 2 displayed remarkable wound healing performance, as well as antioxidative and anti-inflammatory capabilities. The improved antibacterial and wound healing performance were attributed to the synergistic effects of hyperthermia-mediated photothermal therapy (PTT) and reactive oxygen species (ROS)-mediated photodynamic therapy (PDT). This study offers a promising approach for managing maxillofacial wound infections.