The WHO Bacterial Priority Pathogens List 2024: a prioritisation study to guide research, development, and public health strategies against antimicrobial resistance

作者：Hatim Sati, Elena Carrara, Alessia Savoldi, Paul Hansen, Jacopo Garlasco, Enrica Campagnaro, Simone Boccia, Juan Antonio Castillo-Polo, Eugenia Magrini, Pilar García-Vello, Eve E Wool, Valeria Gigante, Erin M Duffy, Alessandro Cassini, Benedikt Huttner, Pilar Ramón-Pardo, Mohsen Naghavi, Fuad Mirzayev, Matteo Zignol, Alexandra Cameron, Evelina Tacconelli, Aaron Aboderin, Majed Al Ghoribi, Jameela Al-Salman, Afreenish Amir, Anucha Apisarnthanarak, Martin Blaser, Amany El-Sharif, Sabiha Essack, Stephan Harbarth, Xun Huang, Geetanjali Kapoor, Gwenan Knight, Jeremiah Chakaya Muhwa, Dominique L. Monnet, Timothée Ousassa, Rosa Sacsaquispe, Juliëtte Severin, Motoyuki Sugai, Neelam Taneja, Alaine Umubyeyi Nyaruhirira · 发表于：The Lancet Infectious Diseases · 年份：2025 · DOI：10.1016/s1473-3099(25)00118-5 · 被引用次数：781 · 研究领域：Antibiotic Use and Resistance、Antibiotic Resistance in Bacteria、Salmonella and Campylobacter epidemiology

BACKGROUND: The 2017 WHO Bacterial Priority Pathogens List (BPPL) has been instrumental in guiding global policy, research and development, and investments to address the most urgent threats from antibiotic-resistant pathogens, and it is a key public health tool for the prevention and control of antimicrobial resistance (AMR). Since its release, at least 13 new antibiotics targeting bacterial priority pathogens have been approved. The 2024 WHO BPPL aims to refine and build on the previous list by incorporating new data and evidence, addressing previous limitations, and improving pathogen prioritisation to better guide global efforts in combating AMR. METHODS: The 2024 WHO BPPL followed a similar approach to the first prioritisation exercise, using a multicriteria decision analysis framework. 24 antibiotic-resistant bacterial pathogens were scored based on eight criteria, including mortality, non-fatal burden, incidence, 10-year resistance trends, preventability, transmissibility, treatability, and antibacterial pipeline status. Pathogens were assessed on each of the criteria on the basis of available evidence and expert judgement. A preferences survey using a pairwise comparison was administered to 100 international experts (among whom 79 responded and 78 completed the survey) to determine the relative weights of the criteria. Applying these weights, the final ranking of pathogens was determined by calculating a total score in the range of 0-100% for each pathogen. Subgroup a...