Ultrasensitive chemiluminescence detection based on titanium-doped spinel-structured nanoparticles with abundant oxygen vacancies

作者：Yutong Liu, Hongzhan Liu, Jiyang Liu, Wenyue Gao, Wei Zhang, Guobao Xu · 发表于：Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · 年份：2025 · DOI：10.1016/j.saa.2025.126240 · 被引用次数：2 · 研究领域：Advanced Nanomaterials in Catalysis、Advanced biosensing and bioanalysis techniques、Carbon and Quantum Dots Applications

We successfully synthesized spinel-structured ternary nanocatalyst Ti-Co 3 O 4 /Fe 3 O 4 nanoparticles (NPs) for the first time. Ti-Co 3 O 4 /Fe 3 O 4 NPs exhibited superior catalytic performance compared to the synthesized binary catalysts Co 3 O 4 /Fe 3 O 4 . Moreover, Ti-Co 3 O 4 /Fe 3 O 4 NPs can enhance the chemiluminescence (CL) intensity of the luminol/H 2 O 2 system by over 3800-fold, attributed to the high density of oxygen vacancies (OVs) within the structure. OVs contribute to electron delocalization, improve conductivity, and are recognized as crucial active sites in the catalytic decomposition of H 2 O 2 . Based on the inhibitory effect of L-ascorbic acid (AA) on the luminol/H 2 O 2 CL system, we developed a sensitive, rapid, effective, and highly selective AA CL assay with a linear range of 0.1 μmol/L to 100 μmol/L and a limit of detection (LOD, S/N = 3) of 0.044 μmol/L. The method was successfully applied to quantify AA in vitamin C tablets with recoveries ranging from 99.7 % to 106.3 %. This research provides a promising prospect for the application of spinel-structured nanoparticles in CL detection platforms and offers valuable insights into nanoparticle size modulation and OV engineering for catalytic optimization.