Bacteroides thetaiotaomicron: A symbiotic ally against diarrhea along with modulation of gut microbial ecological networks via tryptophan metabolism and AHR-Nrf2 signaling

作者：Yuheng Luo, Cong Lan, Wen Ren, Aimin Wu, Bing Yu, Jun He, Daiwen Chen · 发表于：Journal of Advanced Research · 年份：2025 · DOI：10.1016/j.jare.2025.04.016 · 被引用次数：10 · 研究领域：Gut microbiota and health、Animal health and immunology、Immune responses and vaccinations

• The study highlights the beneficial effects of the dominant symbiotic bacterium Bacteroides thetaiotaomicron on intestinal health in pigs, particularly in alleviating post-weaning diarrhea. • It integrates in vivo animal studies, in vivo co-culture systems, and cellular experiments to provide a comprehensive understanding of the mechanisms underlying B. thetaiotaomicron’s probiotic functions. • The research emphasizes how B. thetaiotaomicron modulates gut microbiota composition and microbial ecological network interactions, thereby contributing to the maintenance of intestinal health in young mammals. • B. thetaiotaomicron produces antimicrobial compounds that directly inhibit the growth and colonization of pathogenic bacteria, highlighting its potential as a natural defense against intestinal infections. • In addition, its metabolic products enhance intestinal epithelial barrier integrity, reduce inflammation, and improve mucosal immune responses via the AHR–Nrf2 signaling pathway, further promoting gut health. Bacteroides is a crucial mucosal symbiotic bacterium in mammals, with Bacteroides thetaiotaomicron ( B. thetaiotaomicron ) being particularly noteworthy as a glyco-specialist due to its significant nutritional impact. However, the potential effects of B. thetaiotaomicron on host health remain underexplored. This study aimed to investigate the patterns of microbial community changes and the molecular mechanisms mediated by microbial metabolites in alleviating piglet ...