Comparative study of XGBoost and logistic regression for predicting sarcopenia in postsurgical gastric cancer patients

作者：Yajing Gu, Shu Su, Xianping Wang, Juanjuan Mao, Xuan Ni, Ai Li, Yueli Liang, Xing Zeng · 发表于：Scientific Reports · 年份：2025 · DOI：10.1038/s41598-025-98075-z · 被引用次数：15 · 研究领域：Nutrition and Health in Aging、Gastric Cancer Management and Outcomes、Radiomics and Machine Learning in Medical Imaging

The use of machine learning (ML) techniques, particularly XGBoost and logistic regression, to predict sarcopenia among postsurgical gastric cancer patients has gained significant attention in recent research. Sarcopenia, characterized by the progressive loss of skeletal muscle mass and strength, is a serious concern in these patients due to its association with poor postoperative outcomes, including increased morbidity and mortality. In this study, machine learning was used to establish a risk prediction model for sarcopenia in patients with gastric cancer undergoing gastrectomy to facilitate early intervention and reduce the incidence of postoperative complications. Gastric cancer patients who underwent surgery at a tertiary comprehensive hospital in Nanjing (China) from January 2022 to December 2023 were retrospectively included in this study, and their clinical and follow-up data were collected. The XGBoost model and multivariate logistic regression analysis model were used to screen the factors related to postoperative outcomes, and the results of the two models were compared. The area under the receiver operating characteristic (ROC) curve (AUC), sensitivity and specificity were calculated to evaluate the predictive value of the XGBoost model. The SHAP (SHapley Additive exPlanations) method was used to explain the XGBoost model and determine the impact of features on the prediction model. A total of 231 postoperative gastric cancer patients were included in this study, o...