Bilateral Neck Dissection in cN0 Supraglottic Squamous Cell Carcinoma: Essential or Not?

作者：Jiamei Wen, Chuan Liu, Min Pan, Yanshi Li, Min Wang, Lin Chen, Mengna Wang, Zhaobo Cheng, Guohua Hu · 发表于：Head & Neck · 年份：2025 · DOI：10.1002/hed.28140 · 被引用次数：2 · 研究领域：Head and Neck Cancer Studies、Reconstructive Surgery and Microvascular Techniques、Ear and Head Tumors

ABSTRACT Objective There is controversy regarding bilateral neck dissection for cN0 supraglottic squamous cell carcinoma. This study aimed to explore the risk factor of occult isolated contralateral/bilateral metastasis in cN0 supraglottic squamous cell carcinoma and help clinicians better make assessments for these patients. Method PubMed, the Cochrane Library, CNKI, and CBM were systematically searched for studies on occult lymph node metastasis in cN0 supraglottic squamous cell carcinoma from the inception of each database to May 30, 2024. All patients with supraglottic squamous cell carcinoma and a clinical N0 neck, who had complete records of neck lymph node metastasis, were included in the study. The Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) reporting guideline was followed to extract data. Data were pooled using a random‐effects generalized linear mixed model with 95% confidence intervals (CIs). The risk of occult isolated contralateral/bilateral metastatic lymph nodes was analyzed. Results Fifteen studies including 1609 patients with cN0 supraglottic squamous cell carcinoma were analyzed. The pooled risk of occult isolated contralateral/bilateral metastasis was 7.49% (95% CI: 5.65%–9.87%; I 2 = 57%). For Type A tumors, the risk was 4.14% (95% CI: 2%–64%; I 2 = 81%), 6.74% for Type B (95% CI: 2.27%–18.33%, I 2 = 82%), and 13.62% for Type C (95% CI: 5.82%–28.66%, I 2 = 69%). For T1–T2 patients, the risk was 5.18% (95% CI: 2%–64%; I 2 = ...