Manganese-based nanoparticles plus gambogic acid targeted hypoxic tumor microenvironment by enhancing ROS generation and provided antitumor treatment and improved immunotherapy

作者：Zixin Liang, Xinyi Xu, Ning Wang, Xintao He, Xingzhi Han, Lili Sang, Jing Hu, Xiao-Ping Qian · 发表于：RSC Advances · 年份：2025 · DOI：10.1039/d4ra08547g · 被引用次数：7 · 研究领域：Nanoplatforms for cancer theranostics、Immune cells in cancer、Head and Neck Surgical Oncology

studies using BALB/c mice showed that treatment with MBG NPs significantly reduced tumor volumes and improved survival rates compared to controls. Additionally, MBG NPs combined with programmed death-1 inhibitor (aPD-1) further augmented therapeutic effects. Histological analyses confirmed tumor necrosis and changes in TME composition, indicating the potential of this synergistic strategy to overcome drug resistance in microsatellite stable (MSS) CRC, inhibit tumor growth and benefit patient survival. These findings highlight the promising application of nanoparticle-based platforms in enhancing immunotherapy outcomes for advanced colorectal cancer.