Hierarchical chirality conversion switched by biaxial halogen bonding

作者：Weilong Ma, Zhaozhen Cao, Na Zhang, Aiyou Hao, Pengyao Xing · 发表于：Chemical Science · 年份：2025 · DOI：10.1039/d5sc01441g · 被引用次数：11 · 研究领域：Molecular spectroscopy and chirality、Crystallography and molecular interactions、Liquid Crystal Research Advancements

strong biaxial I⋯N halogen bonds that transform well-ordered helices into amorphous nanoparticles. The biaxial halogen bonding complexation rearranges the assembly with extremely high efficacy, suppressing the supramolecular chirality and recovering the folded molecular chirality, when the chiroptical activities are rationally manipulated. This work unveils the dynamic conversion of artificially folded peptides, which will inspire the design of protocols for peptide- or protein-based chiroptical materials.