Association between mental disorders and trigeminal neuralgia: a cohort study and Mendelian randomization analysis

作者：Jianke Wang, Mingxiao Li, Ze Zhang, Yu Duan, Ziyi Zhang, Hanlin Liu, Ke Yang, Jiang Liu · 发表于：The Journal of Headache and Pain · 年份：2025 · DOI：10.1186/s10194-025-02026-y · 被引用次数：12 · 研究领域：Trigeminal Neuralgia and Treatments、Migraine and Headache Studies、Epilepsy research and treatment

BACKGROUND: Clinical observational evidence suggests a close association between Trigeminal Neuralgia (TN) and Mental disorders (MDs). However, the causal relationship between the two remains unclear. This study aims to observe and analyse the associations between depression, anxiety, insomnia, and TN through clinical research. It also employs Mendelian randomization (MR) analysis to verify the potential genetic correlation between TN and various mental disorders. offering new insights for the diagnosis, prevention, and intervention strategies for TN. METHODS: In the cohort study section, clinical data were collected from 154 patients with TN, all of whom were excluded from preoperative use of psychotropic drugs such as carbamazepine. The PHQ-9, GAD-7, and ISI scales were used to assess preoperative symptoms of depression, anxiety, and insomnia. Multivariable linear regression models were used to identify factors associated with questionnaire scores, with model performance evaluated by adjusted R², AIC, BIC, and p-values. Patients with significant positive symptoms preoperatively were followed up one-year after surgery, and non-parametric tests were employed to examine changes in mental disorder symptoms after pain relief. In MR analysis section, the main MR analysis methods include Inverse Variance Weighted (IVW), MR Egger, Weighted Median, Simple Mode, and Weighted Mode. The Benjamini-Hochberg (BH) method was used to adjust the p -values and control the false discovery rate...