Synthesis of γ-Iodo-allylic Diboronic Esters via Atom Transfer Radical Addition of (Diborylmethyl)iodide to Alkynes

作者：Kun Zhang, Junling Zhang, Qing He, Jiefeng Hu, Su Jing · 发表于：Organic Letters · 年份：2025 · DOI：10.1021/acs.orglett.5c00730 · 被引用次数：10 · 研究领域：Radical Photochemical Reactions、Organoboron and organosilicon chemistry、Sulfur-Based Synthesis Techniques

Herein, we disclose a manganese-catalyzed approach that enables the direct iododiborylcarbofunctionalization of alkynes with a (diboronmethyl)iodide under mild conditions. This approach grants access to a range of structurally unique and synthetically useful γ-iodine-substituted gem -bis(boronate)s, which have hitherto been inaccessible. This atom-economical strategy displays excellent functional-group tolerance, encompasses a wide range of applicable substrates, and demonstrates a high Z: E selectivity (up to 96:4).