Evaluation of scalp-based targeting methods of DLPFC for TMS therapy

作者：Yihan Jiang, Yuanyuan Chen, Lijiang Wei, Farui Liu, Zeqing Zheng, Zong Zhang, Zheng Li, Yingying Tang, Jijun Wang, Qing Xie, Chuanxin M. Niu, Chaozhe Zhu · 发表于：Transcranial magnetic stimulation . · 年份：2025 · DOI：10.1016/j.transm.2025.100095 · 被引用次数：3 · 研究领域：Transcranial Magnetic Stimulation Studies、Advanced Sensor and Energy Harvesting Materials、Neuroscience and Neural Engineering

Repetitive transcranial magnetic stimulation targeting the left dorsolateral prefrontal cortex (DLPFC) provides an effective approach for treating depression. Scalp-based targeting methods, including EEG Cap, Beam F3, Continuous-proportional-coordinate-based (CPC) F3, and adjusted Beam F3, have been proposed. To evaluate the accuracy, reliability, and speed of these four methods. Three trained technicians conducted DLPFC targeting measurements twice on 10 3D-printed head models. Accuracy was assessed based on targeting error and electric field (E-field) strength at the cortical target, which exhibited maximal anti-correlated functional connectivity with the subgenual anterior cingulate. Reliability was evaluated through inter- and intra-rater variability. In terms of targeting accuracy, CPC F3 exhibits the lowest targeting error (4.16 mm), when compared to the EEG cap (7.67 mm), Beam F3 (6.08 mm), and adjusted Beam F3 (6.93 mm); CPC F3 also demonstrates a stronger E-field strength (1.27 V/m) compared to the EEG cap (1.23 V/m), while being comparable to Beam F3 (1.25 V/m) and adjusted Beam F3 (1.26 V/m). Furthermore, CPC F3 shows superior reliability, with inter-rater and intra-rater reliability of 3.30 mm and 2.32 mm, in contrast to EEG F3 (6.40 mm and 4.55 mm), Beam F3 (6.0 mm and 4.37 mm), and adjusted Beam F3 (5.94 mm and 4.28 mm). The EEG cap demonstrated the fastest performance (80 seconds). While CPC F3, Beam F3 and adjusted Beam F3 were comparable in E-field strength, ...