Epidemiology, clinical characteristics, and outcome in candidemia: a retrospective five-year analysis from two tertiary general hospitals

作者：Tingting Liu, Shuhong Sun, Xiaosong Zhu, Hui Wu, Zhiqing Sun, Shanxin Peng · 发表于：BMC Infectious Diseases · 年份：2025 · DOI：10.1186/s12879-025-10908-4 · 被引用次数：15 · 研究领域：Antifungal resistance and susceptibility、Oral health in cancer treatment、Oral microbiology and periodontitis research

BACKGROUND: Candidemia is linked with high mortality, highlighting the critical importance of timely empirical antimicrobial therapy and precise medical intervention before a definite etiologic diagnosis. The current study aimed to investigate the prevalence of pathogens in patients with candidemia and evaluate the potential independent risk factors for Candida albicans bloodstream infections (BSI), as well as the prognosis of candidemia. METHODS: A retrospective bicentric observational study was performed, incorporating 132 candidemia episodes from two tertiary general hospitals in the Linyi area between January 2019 and December 2023. Data on demographic characteristics, underlying diseases, medical intervention, and antimicrobial sensitivity were collected and analyzed using SPSS version 27.0. Univariate analysis and binary logistic regression analyses were performed to identify risk factors for non-albicans Candida infections and candidemia-related mortality. RESULTS: A total of 132 strains of Candida species were isolated from 132 patients with candidemia, with non-albicans Candida accounting for 71.97% (95/132) and Candida albicans for 28.03%. Although Candida albicans remains the predominant species, the proportion of Candida tropicalis, mainly from the Hematology Ward, is approaching that of Candida albicans, which was mainly found in the intensive care unit (ICU) (27.27% versus 28.03%). Moreover, Candida tropicalis, the most frequently isolated non-albicans Candida s...