Development of an eHealth Mindfulness-Based Music Therapy Intervention for Adults Undergoing Allogeneic Hematopoietic Stem Cell Transplantation: Qualitative Study

作者：Sara E. Fleszar‐Pavlović, Blanca S. Noriega Esquives, Padideh Lovan, Arianna E. Brito, A SIA, Mary Adelyn Kauffman, Maria Saudade Oliveira Custódio Lopes, Patricia I. Moreno, Tulay Koru‐Sengul, Rui Gong, Trent Wang, Eric Wieder, Maria Rueda-Lara, Michael H. Antoni, Krishna V. Komanduri, Teresa Lesiuk, Frank J. Penedo · 发表于：JMIR Formative Research · 年份：2025 · DOI：10.2196/65188 · 被引用次数：4 · 研究领域：Cancer survivorship and care、Music Therapy and Health、Mindfulness and Compassion Interventions

Background: Allogeneic hematopoietic stem cell transplantation (allo-SCT) is an effective treatment for various hematologic cancers, though it often results in severe side effects and psychological distress, which can negatively impact health outcomes. Integrative therapies like mindfulness-based stress reduction (MBSR), mindfulness meditation (MM), and music therapy (MT) yield promising results in enhancing both psychosocial outcomes (eg, reducing anxiety and depression) and physiological adaptation (eg, decreasing inflammation) in cancer patients. Objective: We developed and refined, using focus groups and environmental and field testing, an eHealth-delivered mindfulness-based music therapy (eMBMT) intervention aimed at improving health-related quality of life, symptom burden (ie, pain, fatigue, and sleep), disease activity (ie, chronic graft-versus-host disease, cytomegalovirus activation, and infections) and psychosocial (ie, depression, anxiety, and cancer-specific distress) and physiological adaptation (ie, inflammation and immune reconstitution) tailored to adults receiving allo-SCT. Methods: eMBMT intervention content is grounded in MT, MM, and MBSR, developed by a multidisciplinary team, and adapted for adults undergoing allo-SCT. eMBMT content was refined through focus groups and usability and field testing. Focus groups used a semistructured interview guide, while field testing used the "think aloud" method. Usability was evaluated using the 30-item Usefulness, Sat...