Global Consensus Recommendations for Metabolic Dysfunction-Associated Steatotic Liver Disease and Steatohepatitis

作者：Zobair M. Younossi, Shira Zelber‐Sagi, Jeffrey Victor Lazarus, Vincent Wai-Sun Wong, Yusuf Nadir Yilmaz, Ajay Duseja, Yuichiro Eguchi, Laurent Castéra, Mário Guimarães Pessôa, Claudia Pinto Marques Souza de Oliveira, Mohamed El‐Kassas, Emmanuel A. Tsochatzis, Jian-Gao Fan, C Wendy Spearman, Frank Tacke, Marlén Ivón Castellanos Fernández, Naim Alkhouri, Jörn Markus Schattenberg, Manuel Romero‐Gómez, Mazen Noureddin, Alina M. Allen, Janus P. Ong, Stuart Keith Roberts, Jay H. Shubrook, Patrizia Burra, Rohit Kohli, Achim Kautz, Adriaan Georgius Holleboom, Brian P Lam, Scott D. Isaacs, Paula Macedo, Amalia Gastaldelli, Linda L Henry, Dana Ivancovsky Wajcman, Fatema Nader, Leyla de Avila, Jillian Kallman Price, Henry E. Mark, Marcela Villota‐Rivas, Aurora Barberá, Markos Kalligeros, Lynn H. Gerber, Saleh A. Alqahtani · 发表于：Gastroenterology · 年份：2025 · DOI：10.1053/j.gastro.2025.02.044 · 被引用次数：178 · 研究领域：Liver Disease Diagnosis and Treatment、Thyroid Disorders and Treatments、Diabetes, Cardiovascular Risks, and Lipoproteins

BACKGROUND & AIMS: Metabolic dysfunction-associated steatotic liver disease (MASLD) and steatohepatitis (MASH) are associated with adverse clinical outcomes, impaired health-related quality of life, and significant economic burden. The growing burden of MASLD and MASH has led to the publication of a large number of MASLD/MASH guidelines by national and international societies. However, important differences among the recommendations have created confusion, contributing to a low implementation rate and suboptimal management of MASLD and MASH. Creating a consensus recommendation has become more important since the approval of a selective agonist of thyroid hormone β receptor (resmetirom) for MASH treatment in the United States. We built a consensus among the most recently published recommendations for MASLD/MASH. METHODS: A comprehensive search for MASLD and MASH guidelines, guidance documents, or similar publications from January 2018 to January 2025 using PubMed, Embase, Web of Science, and society websites was conducted. Each selected document was assessed across 8 specific domains with 145 variables. Variables with <50% concordance were used for the Delphi statement development. A supermajority threshold of 67% was set for statement acceptance. RESULTS: There were 61 documents published from 2018 through January 2025. Four rounds of Delphi were conducted: 46 statements were generated for Round 1, 32 statements for Round 2, 16 statements for Round 3, and 8 statements for Rou...