The association between traumatic temporomandibular joint bony ankylosis and depressive disorder in growing rats

作者：Tiange Deng, Yang Xue, Yiming Wang, Xiang Guo, Zhen Ma, Hongzhi Zhou, Zaiyong Yang, Zhengwu Peng, Xiangxiang Hu, Ning Li, Kaijin Hu, Lei Wang · 发表于：BMC Oral Health · 年份：2025 · DOI：10.1186/s12903-025-05886-7 · 被引用次数：1 · 研究领域：Temporomandibular Joint Disorders、Orthodontics and Dentofacial Orthopedics、Osteoarthritis Treatment and Mechanisms

BACKGROUND: The psychological symptoms of temporomandibular joint (TMJ) ankylosis were similar to that of depressive disorder, but there were no relevant evidences to confirm that the humans or animals with TMJ ankylosis had depressive disorder. The aim of this study was to investigate the association between TMJ ankylosis and depressive disorder in the rat model. METHODS: Thirty 3-week-old male Sprague-Dawley (SD) rats were used in this study. The damage of TMJ complexes and narrowed joint space were performed in the unilateral TMJ of test group to induce TMJ bony ankylosis (experimental side). The other TMJ of test group underwent a sham operation (sham side). The TMJs of control group did not undergo any operations. At 8 weeks postoperatively, behavioral tests, body weight, passive maximum mouth opening (PMMO), and TMJ morphological features were evaluated, and the hippocampuses were analyzed using western blotting and immunocytochemistry. The data was compared between the test group and control group by independent t-test, between the experimental side and sham side by paired t-test. The correlations between PMMO/area of bony fusion and duration of immobility, sucrose preference, CB1 receptor protein, mean optical density of CB1 receptor protein, and the number of BrdU-positive cell were evaluated using linear regression analysis. The level of significance was 0.05. RESULTS: ) (p < 0.001). There were significant difference with the sucrose preference (test group: 0.36, co...