Disturbing Cholesterol/Sphingolipid Metabolism by Squalene Epoxidase Arises Crizotinib Hepatotoxicity (Adv. Sci. 14/2025)

作者：Hao Yan, Xiangliang Huang, Yourong Zhou, Mu Yuan, Shaoyin Zhang, Yashi Cao, Wentong Wu, Zhifei Xu, Xueqin Chen, Xiaochen Zhang, Xiaohong Wang, Xiaochun Yang, Bo Yang, Qiaojun He, Peihua Luo · 发表于：Advanced Science · 年份：2025 · DOI：10.1002/advs.202570098 · 研究领域：Pharmacological Effects of Natural Compounds、Endoplasmic Reticulum Stress and Disease、Sphingolipid Metabolism and Signaling

Crizotinib Hepatotoxicity In article number 2414923, Peihua Luo, Hao Yan, Xiangliang Huang, and co-workers report the mechanism of crizotinib hepatotoxicity, wherein crizotinib disturbs normal lipid metabolism through accumulation of squalene epoxidase (SQLE). The liver damage caused by crizotinib is similar to persistent sunshine exposure, which causes desertification changes in the “liver land,” whereas rainfall (representing metformin and terbinafine) can prevent such alterations.