A Novel Diathesis-Stress Model of Comorbid Early Onset Psychiatric Disorders

作者：Charlotte Bowers Caswell, Niki Hosseini‐Kamkar, Sylvia M L Cox, Nicole Palacio Prada, Maisha Iqbal, Maja Nikolic, Tobias Banaschewski, Gareth J. Barker, Arun L.W. Bokde, Rüdiger Brühl, Sylvane Desrivières, Herta Flor, Hugh Garavan, Penny Gowland, Antoine Grigis, Andreas Heinz, Jean-Luc Martinot, Marie‐Laure Paillère Martinot, Éric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Michael N. Smolka, Sarah Hohmann, Nilakshi Vaidya, Henrik Walter, Robert Whelan, Günter Schumann, Tomáš Paus, Marco Leyton · 发表于：medRxiv · 年份：2025 · DOI：10.1101/2025.04.08.25325481 · 被引用次数：3 · 研究领域：Child and Adolescent Psychosocial and Emotional Development、Schizophrenia research and treatment、Attention Deficit Hyperactivity Disorder

ABSTRACT Importance Psychiatric comorbidity is the norm. Identifying transdiagnostic risk factors will inform our understanding of developmental pathways and early intervention targets. Objective We recently reported that many psychiatric outcomes are predicted by a three-factor model composed of adolescent externalizing (EXT) behaviors, early life adversity, and dopamine autoreceptor availability. Here, we investigated whether this model could be reproduced in a large population-based sample using functional magnetic resonance imaging (fMRI) instead of positron emission tomography. Design Data were collected by the IMAGEN consortium beginning in 2010 when cohort members were 14 years old, with follow-up testing at ages 16 and 19. These longitudinal data were used to predict psychiatric disorders by 19 years of age. Setting Participants were recruited from secondary schools across Europe. Participants Adolescents (n = 1338) with fMRI, behavioural, diagnostic, and early life trauma data. Main Outcomes and Measures Binary regression models tested whether a combination of EXT behaviors, childhood trauma, and mesocorticolimbic reward anticipation responses at age 14 or 19 predicted the presence of a disorder by age 19. Results A total of 1338 participants had the required data (52.4% female). In all models, EXT and adversity scores were significant predictors ( p < 0.001). Reward anticipation responses in the ventral striatum, caudate, putamen, and anterior cingulate cortex (A...