Association of helicobacter pylori infection with lipid metabolism and 10-year cardiovascular risk in diabetes mellitus: A cross-sectional study

作者：Yuexi Li, Xiaoqin Liu, Qing Li, Peng Zhou, Qian Chen, Bolan Jiang, Taiju Zhu · 发表于：PLoS ONE · 年份：2025 · DOI：10.1371/journal.pone.0319688 · 被引用次数：5 · 研究领域：Helicobacter pylori-related gastroenterology studies、Pathogenesis and Treatment of Hiccups、Whipple's Disease and Interleukins

BACKGROUND: Previous studies have shown that Helicobacter pylori infection is not only a risk factor for gastrointestinal diseases but also associated with various non-digestive conditions. This study aimed to investigate the effect of Helicobacter pylori infection on the risk of lipid metabolism disorders and cardiovascular disease in individuals with diabetes mellitus. METHODS: This cross-sectional study was conducted at a health examination center. Data from life questionnaires, laboratory tests, the carbon-13 urea breath test, and the Framingham Risk Score were collected from 266 patients with diabetes. All participants were categorized into Helicobacter pylori-uninfected and Helicobacter pylori-infected groups based on the carbon-13 urea breath test results. Differences in lipid levels, Framingham Risk Score, and cardiovascular disease risk were compared between the two groups. A logistic regression model was applied to analyze whether Helicobacter pylori infection is an independent risk factor for dyslipidemia in patients with diabetes. RESULTS: Total cholesterol and low-density lipoprotein cholesterol levels were higher in the Helicobacter pylori-infected group than in the uninfected group, and high-density lipoprotein cholesterol levels were lower in the infected group (both P < 0.05). There was no statistically significant difference in triglyceride levels between the two groups. Regression analysis showed that Helicobacter pylori infection was an independent risk fa...