Cell Death Modalities in Therapy of Melanoma

作者：Meng Wang, Jiahui Zhao, Ming Tang, Meng Li, Hu Zhao, Zhongyu Li, Andong Liu · 发表于：International Journal of Molecular Sciences · 年份：2025 · DOI：10.3390/ijms26083475 · 被引用次数：10 · 研究领域：Melanoma and MAPK Pathways、Computational Drug Discovery Methods、CAR-T cell therapy research

Melanoma, one of the most lethal cancers, demands urgent and effective treatment strategies. However, a successful therapeutic approach requires a precise understanding of the mechanisms underlying melanoma initiation and progression. This review provides an overview of melanoma pathogenesis, identifies current pathogenic factors contributing to mortality, and explores targeted therapy and checkpoint inhibitor therapy. Furthermore, we examine melanoma classification and corresponding therapies, along with advancements in various cell death mechanisms for melanoma treatment. We also discuss the current treatment status along with some drawbacks encountered during research stages such as resistance and metastasis.