PROTAC-Surufatinib Suppresses Pancreatic Neuroendocrine Neoplasms Progression by Inducing Ferroptosis through Inhibiting WNT/β-catenin Pathway Mediated by HMOX1

作者：Bingyan Xue, Lijun Yan, Mujie Ye, Danyang Gu, Jianqiang Qian, Na He, Ping Hu, Feiyu Lu, Xintong Lu, Min Liu, Xu Lin, Jian’an Bai, Yan Wang, Guoqin Zhu, Qiyun Tang · 发表于：International Journal of Biological Sciences · 年份：2025 · DOI：10.7150/ijbs.106357 · 被引用次数：9 · 研究领域：Neuroendocrine Tumor Research Advances、Peptidase Inhibition and Analysis、Chromatin Remodeling and Cancer

, P-Surufatinib could obviously suppress the growth of subcutaneous tumors in nude mice and enhance the expressional level of HMOX1 in tumorous tissue. In summary, our findings reveal that P-Surufatinib can suppress pNENs progression via inducing ferroptosis through up-regulating the expressional level of HMOX1 by inhibiting WNT/β-catenin signaling pathway, which provides a novel treatment method for pNENs.