EMC2 promotes breast cancer progression and enhances sensitivity to PDK1/AKT inhibition by deubiquitinating ENO1

作者：Shihan Xiao, Shangxuan Jiang, Chengxu Wen, Han Wang, Wenxiang Nie, Jianguo Zhao, Bo Zhang · 发表于：International Journal of Biological Sciences · 年份：2025 · DOI：10.7150/ijbs.109192 · 被引用次数：7 · 研究领域：Ubiquitin and proteasome pathways、ATP Synthase and ATPases Research

, but made tumor cell sensitive to PDK1/AKT inhibition. Overexpression of EMC2 leads to exactly the opposite result. This study reveals the EMC2/USP7/ENO1/B-MYB protumorigenic axis in breast cancer and identifies EMC2 as a candidate target for PDK1/AKT inhibitory therapy.