Modulation of brain immune microenvironment and cellular dynamics in systemic inflammation

作者：Junhao Wang, Zhaoqian Zhong, Haihua Luo, Qizheng Han, Kan Xing Wu, Aolin Jiang, Li Chen, Yanxia Gao, Yong Jiang · 发表于：Theranostics · 年份：2025 · DOI：10.7150/thno.107061 · 被引用次数：9 · 研究领域：Tryptophan and brain disorders、Neuroinflammation and Neurodegeneration Mechanisms、Immune responses and vaccinations

Through dynamic cellular communication networks, the study revealed that, immune dysregulation in the inflamed brain in SAE involves overactivation of innate immunity, with neutrophils playing a crucial role, providing a scientific framework for developing novel therapeutic strategies and offering new insights into the mechanisms underlying sepsis-induced brain dysfunction.