Nanocatalytic system releases overloaded zinc ions and ROS to induce Znproptosis and interrupt cell cycle through inhibiting Akt/mTOR pathway

作者：Zhijun Xi, C. Fan, Yingying Jiang, Xinran Xi, Gan‐yu Nie, Shuang Zhu, Jun‐Jie Zhang, Lu Xu · 发表于：Theranostics · 年份：2025 · DOI：10.7150/thno.107025 · 被引用次数：12 · 研究领域：Trace Elements in Health

Hence, the research reveals a detailed Znproptosis mechanism in nanocatalytic system. Through regulating FDX2/LIAS pathway, Znproptosis could improve the death rate of mitochondria by decreasing the production of Fe-S protein, contributing to advancements in the field of antitumor therapy.