PD-1 activation mitigates lupus nephritis by suppressing hyperactive and heterogeneous PD-1 + CD8 + T cells

作者：Jun Deng, Zhu Junling, Xiaoyue Jiang, Chao Yao, Haifeng Chen, Yanjie Ding, Peng Niu, Qian Chen, Huihua Ding, Nan Shen · 发表于：Theranostics · 年份：2025 · DOI：10.7150/thno.107418 · 被引用次数：10 · 研究领域：Systemic Lupus Erythematosus Research、Atherosclerosis and Cardiovascular Diseases、Liver Diseases and Immunity

T cells in LN are hyperactive, clonally expanded, and contribute to disease progression. Targeting the PD-1/PD-L1 pathway with PD-L1 Fc effectively reduced kidney pathology in a murine model of LN, underscoring the potential of modulating PD-1 signaling as a treatment strategy for LN.