Gene Signature-Based Prognostic Model for Acute Myeloid Leukemia: The Role of BATF , EGR1 , PD-1 , PD-L1 , and TIM-3

作者：Yupei Zhang, Zhixi Chen, Jiamian Zheng, Shaohua Chen, Li-Ye Zhong, Jie Chen, Cunte Chen, Songnan Sui, Yangqiu Li · 发表于：International Journal of Medical Sciences · 年份：2025 · DOI：10.7150/ijms.108527 · 被引用次数：4 · 研究领域：Histone Deacetylase Inhibitors Research、Lung Cancer Treatments and Mutations、Cancer-related gene regulation

Background: Acute myeloid leukemia (AML) is a malignancy of hematopoietic stem and progenitor cells, with T cell exhaustion linked to poor outcomes.Our previous research has shown that basic leucine zipper ATF-like transcription factor (BATF) and early growth response 1 (EGR1) play a role in chimeric antigen receptor T (CAR-T) cell exhaustion during AML tumor elimination.However, the roles of BATF and EGR1 and their association with immune checkpoint genes in AML prognosis remain underexplored.Methods: Bone marrow (BM) samples from 92 newly diagnosed AML patients at our clinical center (JUN-dataset) were analyzed to detect the expression levels of BATF, EGR1, programmed cell death 1 (PD-1), programmed death-ligand 1 (PD-L1), T cell immunoglobulin and mucin domain-containing protein 3 (TIM3) together with conducting a prognostic assessment.Our findings were validated using RNA sequencing data from 155 AML patients from the TCGA database and 199 AML patients from the Beat-AML database.Results: High BATF expression correlated with poor overall survival (OS) (P = 0.030), whereas high EGR1 expression indicated a favorable prognosis (P = 0.040).Patients with high BATF and low EGR1 expression had worst outcomes (P < 0.001).Among those receiving allogenic hematopoietic stem cell transplantation (allo-HSCT), high BATF expression was linked to shorter OS (P = 0.004).Moreover, a prognostic model incorporating BATF, EGR1, PD-1, PD-L1, and TIM-3 calculated a risk score, with high-risk pat...