Marine Natural Products in Inflammation‐Related Diseases: Opportunities and Challenges

作者：Tao Zhang, Zijun Ouyang, Yueran Zhang, Haiyan Sun, Lingdong Kong, Qiang Xu, Jiao Qu, Yang Sun · 发表于：Medicinal Research Reviews · 年份：2025 · DOI：10.1002/med.22109 · 被引用次数：15 · 研究领域：Marine Sponges and Natural Products、Seaweed-derived Bioactive Compounds、Inflammatory mediators and NSAID effects

In recent decades, the potentiality of marine natural products (MNPs) in the medical field has been increasingly recognized. Natural compounds derived from marine microorganisms, algae, and invertebrates have shown significant promise for treating inflammation-related diseases. In this review, we cover the three primary sources of MNPs and their diverse and unique chemical structures and bioactivities. This review aims to summarize the progress of MNPs in combating inflammation-related diseases. Moreover, we cover the functions and mechanisms of MNPs in diseases, highlighting their functions in regulating inflammatory signaling pathways, cellular stress responses, and gut microbiota, among others. Meanwhile, we focus on key technologies and scientific methods to address the current limitations and challenges in MNPs.