The role of long non-coding RNAs in angiogenesis in ischemic stroke: new perspectives based on advanced techniques in neuroscience

作者：Shihao Zhou, Yi Yang, Na Qiu, Ti Yang · 发表于：Advanced technology in neuroscience . · 年份：2025 · DOI：10.4103/atn.atn-d-24-00030 · 被引用次数：6 · 研究领域：Cancer-related molecular mechanisms research、Circular RNAs in diseases、Lipid metabolism and disorders

Ischemic stroke is a leading cause of long-term disability and death, making it crucial to understand the underlying cellular and molecular mechanisms. Research into these mechanisms has gained significant attention, with a particular focus on long noncoding RNAs, which are greater than 200 nucleotides in length. Recent studies using RNA sequencing, deep sequencing, and microarrays have identified numerous long non-coding RNAs that are aberrantly expressed in both patients with ischemic stroke and animal models of ischemic injury. In recent years, research on long non-coding RNAs has identified various types that exhibit both vascular protective effects and harmful effects, which are related to the regulation of vascular regeneration in the nervous system. These findings offer new targets for the study of ischemic stroke. The purpose of this review is to summarize the current research progress on the role of long non-coding RNAs in angiogenesis after ischemic stroke and to explore their potential clinical significance and new technologies. With advances in new technologies, such as RNA sequencing and deep sequencing, researchers can gain deeper insights into the functions and mechanisms of long noncoding RNAs. The application of these technologies has not only enhanced the understanding of the role of long non-coding RNAs in stroke but also opened up possibilities for the development of new therapeutic strategies. This review highlights the critical roles of long non-coding R...