Effect of tranexamic acid-functionalized photothermal hydrothermal treated oxidized graphene sponge on diabetic wound healing: Hemostasis, antibacterial, and regeneration

作者：Chaoyang Huang, L. Chen, Xiaoyang Liu, Ying-Cheng Chen, Xian Li, Qiulan Wen, Hai Zhou, Bo Liu, Lei Yang, Pengwei Shi · 发表于：Materials & Design · 年份：2025 · DOI：10.1016/j.matdes.2025.113915 · 被引用次数：11 · 研究领域：Graphene and Nanomaterials Applications、Electrospun Nanofibers in Biomedical Applications、Wound Healing and Treatments

• The PGO 0.35 T 1 sponge, via photothermal conversion, not only enhances cellular adaptation to oxygen levels but also reshapes the local tissue microenvironment, thereby effectively regulating cell respiration. • This graphene oxide photothermal hot bath sponge can absorb a large amount of light energy and achieve the purpose of killing bacteria through the local high temperature thermal effect. • The functional modification of tranexamic acid gives the graphene oxide sponge good hemostatic performance. In the healing process of chronic diabetic wounds, a prolonged inflammatory phase and an increased number of inflammatory cells consuming large amounts of oxygen create a hypoxic environment around the wound. Under such conditions, prolonged hypoxia inhibits angiogenesis and extracellular matrix synthesis, reducing the nutrient supply to the injured area, thereby impeding further healing. Therefore, promoting tissue vascularization and enhancing nutrient delivery are crucial for facilitating tissue repair processes. To address this issue, we developed a graphene oxide-decellularized dermal matrix sponge (PGO 0.35 T 1 ) with photothermal bath functionality. Through photothermal conversion, this sponge not only enhances cellular adaptation to oxygen and remodels the local tissue microenvironment, effectively regulating cellular metabolism, but also absorbs substantial light energy, achieving bacterial eradication via localized hyperthermia. Additionally, owing to the modificat...