Clinical risk factors for postoperative infection in adult cardiac surgery with cardiopulmonary bypass: a retrospective study

作者：G. Le Mao, Wensen Chen, Liyun Wang, Sheng Zhao, Feng Zang · 发表于：Infection Prevention in Practice · 年份：2025 · DOI：10.1016/j.infpip.2025.100458 · 被引用次数：5 · 研究领域：Nosocomial Infections in ICU、Surgical site infection prevention、Cardiac and Coronary Surgery Techniques

Background Postoperative infection remains a serious problem for patients undergoing open-heart surgery and is associated with poor prognosis and mortality. Aim To determine the incidence, characteristics and associated risk factors for nosocomial infections in adult cardiac surgery patients and to develop a nomogram prediction model. Methods Data were retrospectively collected from patients who underwent cardiac surgery with cardiopulmonary bypass (CPB) at a tertiary hospital in 2023. Patients were divided into an infected group ( N = 130) and a non-infected group ( N = 192). Multivariate logistic regression analysis was used to analyse the independent risk factors for healthcare-associated infections after cardiac surgery under CPB. Results Of the 1584 patients, 130 (8.21%) developed postoperative infections (infection group). Lower respiratory tract was the most common site of infection ( N = 74, 56.9%), while Gram-negative bacteria were the predominant isolates overall ( N = 81, 62.3%). Among the Gram-negative bacteria, Acinetobacter baumannii was the most frequently identified, whereas Staphylococcus aureus was the leading strain among Gram-positive bacteria. Multivariate logistic regression analysis of the 322 patients included in the study revealed that CPB duration, American Society of Anaesthesiologists score, procalcitonin concentration on the first postoperative day, monocyte :lymphocyte ratio, preinfection mechanical ventilation duration, and preinfection central ...