Near-Infrared Multifunctional Antitumor Nanomaterial of Bismuth Sulfide Heterojunction Coupled with Mesoporous Polydopamine

作者：Juanxuan Guo, Biling Chen, Menglong Zhao, Wenbin Chen, Si-Qi Qiu, Ming‐De Li, Li Dang · 发表于：ACS Applied Bio Materials · 年份：2025 · DOI：10.1021/acsabm.5c00313 · 被引用次数：4 · 研究领域：Nanoplatforms for cancer theranostics、Quantum Dots Synthesis And Properties、Advanced Photocatalysis Techniques

Bismuth sulfide@bismuth nanorods (Bi 2 S 3 @Bi NRs) have emerged as promising photodynamic therapeutic agents due to Bi 2 S 3 @Bi being able to produce reactive oxygen species from self-supplied O 2 . Combining photothermal and photodynamic therapies with chemotherapy is attractive but difficult to achieve. Here, we develop a subtle method to wrap Bi 2 S 3 @Bi NRs with photothermal mesoporous polydopamine, where chemotherapy drug doxorubicin hydrochloride can be loaded, thus providing multifunctional antitumor nanospheres. To our delight, the prepared triple-functional material exhibits excellent antitumor efficacy toward tumor cells under near-infrared light irradiation. This multifunctional antitumor nanomaterial is not only biocompatible but also suitable for tumor hypoxic microenvironments, having much better efficacy than single- or double-functional materials. This study highlights the great potential of combining photothermal, photodynamic, and chemotherapies.