Brain Structural and Functional Neuroimaging Features are Associated With Improved Auditory Hallucinations in Patients With Schizophrenia After Real‐Time fMRI Neurofeedback

作者：Jiahe Zhang, Emma Tusuzian, Francesca Morfini, Clemens Bauer, Lena Stone, Angelina Awad, Ann K. Shinn, Margaret Niznikiewicz, Susan Whitfield‐Gabrieli · 发表于：Depression and Anxiety · 年份：2025 · DOI：10.1155/da/2848929 · 被引用次数：9 · 研究领域：Functional Brain Connectivity Studies、Neuroscience and Music Perception、Hallucinations in medical conditions

Auditory hallucinations (AHs) are debilitating and often treatment‐resistant symptoms of schizophrenia (SZ). Real‐time functional magnetic resonance imaging (fMRI) neurofeedback (NFB) is emerging as a flexible brain circuit‐based tool for targeting AH via self‐modulation of brain activity. A better understanding of what baseline characteristics predict NFB success will enhance its clinical utility. Previous work suggests that AH symptomology implicates measures across multiple modalities, including T1 structural MRI (sMRI), diffusion‐weighted MRI (dMRI), and resting‐state fMRI (rsfMRI). Specifically, AH severity and treatment response are associated with thinner superior temporal gyrus (STG), thinner dorsolateral prefrontal cortex (DLPFC), reduced white matter integrity in tracts connecting brain regions implicated in SZ symptomatology, increased within‐default mode network (DMN) connectivity, and reduced DMN–DLPFC anticorrelation. In this study, we tested the individual and combined contributions of multimodal brain features for the prediction of AH change after NFB in adults ( N = 25, 36.1 ± 10.0 years, 24% females) with SZ spectrum disorders (SZ or schizoaffective disorder) and frequent medication‐resistant AH. Participants underwent a baseline MRI scan (including sMRI, dMRI, and rsfMRI) and were randomly assigned to receive NFB from their STG ( n = 12, real condition) or NFB from their motor cortex (MC) ( n = 13, sham condition). NFB success was operationalized as the imp...