Direct inhibition of the TXNIP-NLRP3-GSDMD pathway reduces pyroptosis in colonocytes and alleviates ulcerative colitis in mice by the small compound PEITC

作者：Jie Wang, Cui Zhang, Jia Qin, Ning An, Mei Bai, Ronghui Du, Yan Shen, Xudong Wu, Jingcai Cheng, Xue-Feng Wu, Qiang Xu · 发表于：Acta Pharmacologica Sinica · 年份：2025 · DOI：10.1038/s41401-025-01549-z · 被引用次数：13 · 研究领域：Inflammasome and immune disorders、Gout, Hyperuricemia, Uric Acid、Trace Elements in Health