Multiple ways to promote adult grass carp (Ctenopharyngodon idella) muscle hypertrophy: Application of dietary myo-inositol

作者：Meiqi Wang, Lin Feng, Pei Wu, Yang Liu, Hongmei Ren, Xiao‐Wan Jin, Xiaoqiu Zhou, Wei‐Dan Jiang · 发表于：Animal nutrition · 年份：2025 · DOI：10.1016/j.aninu.2025.01.010 · 被引用次数：4 · 研究领域：Muscle Physiology and Disorders、Physiological and biochemical adaptations、Genetics and Physical Performance

< 0.05). This implies that MI promotes muscle hypertrophy. The hypertrophic effect of MI was primarily ascribed to an increase in the number of myonuclear and enhanced protein synthesis, which is associated with the regulation of the skeletal muscle lysyl oxidase (LOX) and the protein kinase B (AKT)/target of rapamycin (TOR)/ribosomal protein S6 kinase 1 (S6K1) signaling pathways. Additionally, MI inhibited the myostatin (MSTN) and the forkhead box O3 (FoxO3)/muscle RING-finger protein-1 (MuRF1)/muscle atrophy F-box (MAFbx) pathways, which are involved in muscle atrophy and protein degradation. Based on PWG, the appropriate MI requirement of adult grass carp was determined to be 301.30 mg/kg. This study offers a preliminary theoretical foundation for the potential mechanism by which MI promotes muscle hypertrophy in fish and furnishes a reference for the commercial feed formulation of adult grass carp.