The Development and Challenges of PET / MRI Dual‐Modality Imaging Probes—An Update

作者：Maryam Sabbaghan, Saumya Nigam, Isabella Kasabasic, Medha Manepalli, Ping Wang, Jinda Fan · 发表于：Journal of Magnetic Resonance Imaging · 年份：2025 · DOI：10.1002/jmri.29779 · 被引用次数：4 · 研究领域：Medical Imaging Techniques and Applications、Radiopharmaceutical Chemistry and Applications、Advanced MRI Techniques and Applications

The integration of Positron emission tomography (PET) with Magnetic resonance imaging (MRI) combines the functional imaging capabilities of PET with the high-resolution anatomical detail of MRI, creating a synergistic platform for advanced diagnostic imaging and image-guided therapies. Central to the success of this dual-modality system is the development of specialized PET/MRI dual-modality probes, particularly those capable of simultaneous functionality, which present significant technical challenges in synthesis and applications. This review explores the advancements in PET/MRI probe development, summarizes the current applications, and highlights the critical challenges in translating PET/MRI probes from experimental research to clinical applications, offering insights into the future direction of this transformative imaging technology. EVIDENCE LEVEL: 5. TECHNICAL EFFICACY: Stage 1.