Engineered Exudate Trap with Programmable Enrichment and Force‐Controlled Therapy Pump toward Diabetic Burn Personalized Treatment

作者：Zhengxin Ma, Peng Xu, Yang Liu, Peng Yu, Hongbo Zhang, Qiangwei Xin, Shiran Sun, Liwei Zheng, Mingming Ding, Meng Qin, Chunmei Ding, Jianshu Li · 发表于：Advanced Functional Materials · 年份：2025 · DOI：10.1002/adfm.202501844 · 被引用次数：6 · 研究领域：Wound Healing and Treatments、Burn Injury Management and Outcomes、Planarian Biology and Electrostimulation

Abstract Personalized treatment is an effective approach that provides customized therapeutic regimens. However, existing personalized treatment strategies often require complex designs, which are challenging to implement and susceptible to failure. By virtue of the widespread mechanical environment in the human body, a force‐controlled therapy pump is reported for controlled release and individualized therapy. Similar to a fish trap, the pump is composed of a hydrophobic trammel film with random microfibers, a hydrophobic cover film with aligned microfibers, and an inner hydrophilic sponge loaded with bletilla striata polysaccharide‐confined nano cerium oxide (BCe). BCe possesses excellent reactive oxygen species (ROS) scavenging ability (, H 2 O 2 , and ·OH) due to the small cerium oxide particle size (2.6 ± 0.8 nm) and high Ce 3+ ratio (66.19%). The trap programmatically enriches exudate and enables force‐controlled release of BCe through massage (0.1–1.38 N), achieving personalized treatment as a therapy pump. The inflammatory phase is shortened by blocking TNF and NF‐κB signaling pathways, while activating the PI3K‐AKT signaling pathway associated with cell migration and angiogenesis. The healing rate of diabetic burn wounds (92.3%) surpasses that of the commercial drug. This strategy is suitable for treatments in mechanically induced environments, offering a reference for personalized medicine.