Navigating the future of gastric cancer treatment: a review on the impact of antibody-drug conjugates

作者：Qingling Yin, Yanlong Zhang, Xueqing Xie, Meijun Hou, Xunsheng Chen, Jie Ding · 发表于：Cell Death Discovery · 年份：2025 · DOI：10.1038/s41420-025-02429-5 · 被引用次数：10 · 研究领域：Gastric Cancer Management and Outcomes、HER2/EGFR in Cancer Research、Gastrointestinal Tumor Research and Treatment

Gastric cancer, marked by its high incidence and poor prognosis, demands the urgent development of novel and effective treatment strategies, especially for patients ineligible for surgery or those who have had limited success with chemotherapy, radiotherapy and targeted therapies. Recently, antibody-drug conjugates (ADCs) have become a key area of investigation due to their high specificity and potent antitumor effects. These therapies combine monoclonal antibodies, designed to bind to tumor-specific antigens, with cytotoxic agents that selectively target and destroy malignant cells. ADCs have generated significant interest in clinical trials as a promising approach to improve both treatment efficacy and patient outcomes in gastric cancer. However, their clinical application is not without challenges and limitations that must be addressed. This review discusses the recent progress in the use of ADCs for gastric cancer treatment.