Spatial and temporal distribution patterns and factors influencing hepatitis B in China: a geo-epidemiological study

作者：Kang Fang, Na Cheng, Chuang Nie, Wentao Song, Yunkang Zhao, Jie Pan, Yin Qi, Jiwei Zheng, Qing‐Lin Chen, Tianxin Xiang · 发表于：BMC Public Health · 年份：2025 · DOI：10.1186/s12889-025-22452-6 · 被引用次数：7 · 研究领域：Hepatitis B Virus Studies、Data-Driven Disease Surveillance、Hepatitis Viruses Studies and Epidemiology

BACKGROUND: China is a country with an extremely high disease burden of hepatitis B. Spatiotemporal analysis of hepatitis B from a socioeconomic perspective is of great significance for reducing the disease burden, but there is still a relative lack of research. METHODS: The age-period-cohort model and spatial distribution maps describe the three-dimensional distribution characteristics of hepatitis B. Spatial autocorrelation analysis and spatiotemporal scanning were used to analyze the spatiotemporal distribution characteristics. The random forest algorithm was used to screen the potential influencing factors. The geographic detector model was used to analyze the interaction patterns of variables. Finally, a geographically and temporally weighted regression model was established to analyze the effects of variables on the incidence rate of hepatitis B at different spatiotemporal scales. RESULTS: From 2004 to 2023, a total of 20,376,898 cases of hepatitis B were reported in China. The incidence rate of hepatitis B decreased at a rate of 3.31% per year, and hepatitis B vaccination has led to this downward trend, accompanied by a significant birth cohort effect. And it shows an aggregated characteristic, which highlights the inequality of geographical distribution. Stronger explanations for the incidence of hepatitis B were found for the number of people at the end of each year (q = 0.1949; where q value refers to the explanatory ability of the independent variable for the depen...