Systemic inflammation in response to radiation drives the genesis of an immunosuppressed tumor microenvironment

作者：Lin Ma, Jian‐Hua Mao, Mary Helen Barcellos‐Hoff · 发表于：Neoplasia · 年份：2025 · DOI：10.1016/j.neo.2025.101164 · 被引用次数：7 · 研究领域：Effects of Radiation Exposure、Cancer, Stress, Anesthesia, and Immune Response、Cancer Immunotherapy and Biomarkers

The composition of the tumor immune microenvironment has become a major determinant of response to therapy, particularly immunotherapy. Clinically, a tumor microenvironment lacking lymphocytes, so-called "cold" tumors, are considered poor candidates for immune checkpoint inhibition. In this review, we describe the diversity of the tumor immune microenvironment in breast cancer and how radiation exposure alters carcinogenesis. We review the development and use of a radiation-genetic mammary chimera model to clarify the mechanism by which radiation acts. Using the chimera model, we demonstrate that systemic inflammation elicited by a low dose of radiation is key to the construction of an immunosuppressive tumor microenvironment, resulting in aggressive, rapidly growing tumors lacking lymphocytes. Our experimental studies inform the non-mutagenic mechanisms by which radiation affects cancer and provide insight into the genesis of cold tumors.