Intrapleural pressure-controlled piezo-catalytic nanozyme for the inhibition of malignant pleural effusion

作者：Zihan Xu, Xiujing He, Yu Gui, Lingkai Tang, Yuxin Zhao, Linlin Song, Tianyue Xu, Meixu Chen, Yujie Zhao, Peixin Du, Xin Wang, Siyi Chen, Yong Luo, Feng Luo, Huan Meng, Jianping Hu, Wei Zhuo, Jing Jing, Hubing Shi · 发表于：Nature Communications · 年份：2025 · DOI：10.1038/s41467-025-58354-9 · 被引用次数：11 · 研究领域：Nanoplatforms for cancer theranostics、MXene and MAX Phase Materials、Graphene and Nanomaterials Applications

Malignant pleural effusion is a challenge for cancer therapy. Here, the authors report on a piezoelectric nano-system that inhibits tumor growth in the thoracic cavity by piezo-generated reactive oxygen species using the intrapleural pressure, triggering immunogenic cell death, to treat malignant pleural effusion.