Canumycins A–E, Macrocyclic Napyradiomycins from a Marine-Derived Streptomyces canus

作者：Min Hao, Cheng‐Lei Qu, Yuan Deng, Lin Guo, Tianyun Jin, Maolei Xu, Pei Wang, Wei Guo, Lijuan Kou, Shumin Zhang, Gui‐Ge Hou, Zeping Xie · 发表于：Organic Letters · 年份：2025 · DOI：10.1021/acs.orglett.5c00472 · 被引用次数：4 · 研究领域：Microbial Natural Products and Biosynthesis、Synthesis and Biological Activity、Marine Sponges and Natural Products

Five new macrocyclic napyradiomycins with different types of scaffolds were isolated from marine-derived Streptomyces canus SJ-019. Compounds 1 and 2 are uniquely typified by a spirocyclic core, while 1, 2 and 4 also contain a unique macrolide structure not known in any other napyradiomycins. Compound 3 is composed of a dearomatized napyradiomycin core and an intramolecular double-arch bridge system. Compound 4 displays potent inhibition of Staphylococcus aureus, while C-type napyradiomycin 5 shows notable anti-inflammatory effect.