Individual-level deviations from normative brain morphology in violence, psychosis, and psychopathy

作者：Unn K. Haukvik, Thomas Wolfers, Natalia Tesli, Christina Bell, Gabriela Hjell, Thomas Fischer-Vieler, Nina Bang, Ingrid Melle, Ole A. Andreassen, Kirsten Rasmussen, Ingrid Agartz, Lars T. Westlye, Christine Friestad, Jaroslav Rokicki · 发表于：Translational Psychiatry · 年份：2025 · DOI：10.1038/s41398-025-03343-1 · 被引用次数：10 · 研究领域：Psychopathy, Forensic Psychiatry, Sexual Offending、Psychosomatic Disorders and Their Treatments、Schizophrenia research and treatment

Neuroimaging research has shown brain morphological abnormalities associated with violence and psychosis, but individual differences are substantial and results not consistent across studies. Normative modeling of brain MRI-features facilitates a systematic mapping of individual brain characteristics of complex phenotypes also in small samples but has not yet been applied to forensic psychiatry populations. We explored brain heterogeneity in persons with a history of severe violence with a comorbid schizophrenia spectrum disorder (SSD-V; n = 38), non-violent persons with schizophrenia spectrum disorders (SSD-NV; n = 138), persons with a history of severe violence without comorbid schizophrenia spectrum disorder (nonSSD-V; n = 20), and healthy non-violent participants (HC; n = 196) from lifetime normative trajectories of cortical thickness, surface area, and subcortical volumes. Normative models based on Freesurfer derived regions of interest from 58,836 individuals were used to investigate individual deviances, group differences, and associations to psychopathy traits. We found overall heterogeneous patterns of individual deviations from the norm, which were most prominent for regions within the collateral transverse sulcus, lingual gyrus, and cerebellum among SSD-V, a pattern that differed from SSD-NV (parieto-occipital and suborbital sulci), and nonSSD-V (paracentral and middle frontal regions). We found no significant associations to psychopathy traits. By applying normati...