Changes in the Prevalence of Non-AIDS Conditions Among Hospitalized Persons With HIV in the United States and Canada, 2008–2018

作者：Thibaut Davy-Méndez, Sonia Napravnik, Brenna Hogan, Joseph J. Eron, Kelly A. Gebo, Keri N. Althoff, Richard D. Moore, Michael J. Silverberg, Michael A. Horberg, M. John Gill, Jonathan Colasanti, Ank E. Nijhawan, Maile Karris, Marina B. Klein, Raynell Lang, Catherine R. Lesko, George A. Yendewa, Gregory D. Kirk, Kathleen A. McGinnis, Stephen A. Berry, Constance A. Benson, Ronald J Bosch, Gregory D Kirk, Alan E. Greenberg, Amanda D Castel, Anne K. Monroe, Vincent Marconi, Jonathan Colasanti, Kenneth H Mayer, Chris Grasso, Robert S Hogg, Viviane D Lima, Julio S G Montaner, Kate Salters, Kate Buchacz, Jun Li, Kelly A Gebo, Moore Rd, Moore Rd, John T. Carey, Jeffrey Jacobson, George A Yendewa, Michael A Horberg, Michael J Silverberg, Jennifer E Thorne, Todd Brown, Phyllis Tien, Gypsyamber D'Souza, Graham Smith, Mona Loutfy, Meenakshi Gupta, Marina B Klein, Charles Rabkin, A Kroch, Ann Burchell, Adrian Betts, Joanne Lindsay, Ank Nijhawan, Ángel M. Mayor, M John Gill, Jeffrey N Martin, Steven G Deeks, Jun Li, John T Brooks, Michael S Saag, Michael J Mugavero, Burkholder Gv, Laura Bamford, Maile Karris, J Eron, S Napravnik, Mari M Kitahata, Heidi M Crane, Timothy R Sterling, David Haas, Peter Rebeiro, Megan Turner, Kathleen McGinnis, A C Justice, Moore Rd, Keri N Althoff, Gange Sn, Mari M Kitahata, Jennifer S Lee, Michael S Saag, Michael A Horberg, Marina B Klein, Rosemary G. McKaig, Aimee Freeman, Moore Rd, Keri N Althoff, Aimee Freeman, Mari M Kitahata, Stephen E. Van Rompaey, Heidi M Crane, Justin McReynolds, Justin McReynolds, William B Lober, Gange Sn, Jennifer S Lee, Brenna Hogan, Elizabeth Humes, Raynell Lang, Sally Coburn, Lucas Gerace, Cameron Stewart · 发表于：Clinical Infectious Diseases · 年份：2025 · DOI：10.1093/cid/ciaf167 · 被引用次数：2 · 研究领域：HIV-related health complications and treatments、HIV/AIDS Research and Interventions、Hepatitis C virus research

BACKGROUND: Hospitalization causes among persons with HIV (PWH) have shifted to non-AIDS conditions, but the complete disease profile of hospitalized PWH has not been well described. To inform hospitalization and readmission prevention efforts, we examined non-AIDS disease prevalence among PWH hospitalized in 4 US cohorts and 1 Canadian cohort. METHODS: Among PWH with ≥1 hospitalization from 2008 to 2018, we used log-binomial regression with generalized estimating equations to estimate trends in the annual prevalence of hepatitis B virus (HBV), hepatitis C virus (HCV), hypertension, hyperlipidemia, diabetes mellitus, chronic kidney disease (CKD) stage ≥3, and multimorbidity (≥2 and ≥3 conditions), defined using longitudinal diagnosis, medication, and laboratory data. RESULTS: We examined 6781 hospitalized PWH who were 75% cisgender men, 40% White, and 38% Black. From 2008 to 2018, the proportion of PWH in care who had ≥1 hospitalization decreased from 9.6% to 6.3%. Age- and cohort-adjusted prevalence increased for hyperlipidemia (relative change per year: 3.6% [95% CI: 2.5%-4.7%]), diabetes mellitus (2.8% [1.3%-4.4%]), CKD (3.3% [1.7%-4.9%]), ≥2 conditions (1.3% [0.6%-2.0%]), and ≥3 conditions (3.0% [1.7%-4.3%]), decreased for HCV infection (-2.0% [-3.0%, -0.9%]), and remained stable for HBV infection (1.6% [-1.1%, 4.3%]) and hypertension (0.4% [-0.2%, 1.1%]). CONCLUSIONS: Hospitalized PWH had an increasing burden of several non-AIDS conditions and multimorbidity not accounte...