Hydrogen-bonded organic framework for regulating pathogenic autoantigen and oxidative stress in psoriasis treatment

作者：Yuhang Li, Hui Yuan, Yi-Lun Cheng, Qiuxia Li, Rong Cao, Jinlin Li, Qi Yin, Can‐Zhong Lu, Tian‐Fu Liu · 发表于：National Science Review · 年份：2025 · DOI：10.1093/nsr/nwaf132 · 被引用次数：10 · 研究领域：Synthesis and biological activity、Synthesis and Characterization of Heterocyclic Compounds、Click Chemistry and Applications

This study develops a cobalt porphyrin-based hydrogen-bonded organic framework (Co-HOF) to scavenge reactive oxygen species (ROS) and target the pathogenic peptide LL-37, thereby disrupting psoriasis progression.