Global epidemiology and burden of headache disorders in children and adolescents from 1990 to 2021

作者：Guangshuang Lu, Shaobo Xiao, Yun Wang, Qiuyu Jia, Shengnan Liu, Shengyuan Yu, Ruozhuo Liu, Wu Yang · 发表于：Headache The Journal of Head and Face Pain · 年份：2025 · DOI：10.1111/head.14937 · 被引用次数：15 · 研究领域：Migraine and Headache Studies、Cerebral Venous Sinus Thrombosis、Neurological Complications and Syndromes

OBJECTIVE: We aimed to present an updated epidemiological overview of headache disorders among children and adolescents, utilizing the latest data from the Global Burden of Disease (GBD) 2021. BACKGROUND: Large-sample epidemiological studies on headache disorders in children and adolescents have been limited due to their demographic uniqueness, with previous GBD studies rarely focusing on this age group, until the GBD 2021 study provided a significant update. METHODS: A secondary analysis of headache disorder data from the GBD 2021 for individuals aged 0-<20 years was conducted. The analysis focused on estimating the prevalence, incidence, and disability-adjusted life-years (DALYs), as well as the estimated annual percentage changes (EAPCs). Data from 204 countries and regions, stratified by sociodemographic index (SDI), were included to assess variations in headache disorder metrics across different age groups, sexes, and socioeconomic settings. RESULTS: Between 1990 and 2021, the global prevalence, incidence, and DALYs of headache disorders in children and adolescents rose by 22.79% (95% uncertainty interval [UI] 21.68-23.82%), 5.21% (95% UI 4.26-6.10%), and 24.27% (95% UI 20.35-26.91%) per 100,000 population, respectively. In 2021, 545,824,485 (95% UI 448,777,920-641,644,106) children and adolescents were affected, with a prevalence of 20.71% (95% UI 17.03-24.34%). Migraine affected 205,729,235 (95% UI 158,825,540-265,306,014) with a prevalence of 7.81%, and tension-type h...