Neuro–astrocytic network in breast cancer brain metastases: Adaptive mechanisms and novel therapeutic targets

作者：Tao Huang, Dongbo Wu, Lu Jiang, Zepei Wu, Yubo Zhao, Fansong Tang, Zhenglin Mou, Caihou Pan, Yi Liu, Aiping Tong, Liangxue Zhou, Jianguo Xu, Yuelong Wang · 发表于：International Journal of Cancer · 年份：2025 · DOI：10.1002/ijc.35421 · 被引用次数：4 · 研究领域：Brain Metastases and Treatment、Glioma Diagnosis and Treatment、Lung Cancer Research Studies

Breast cancer brain metastases (BrM) are a common and fatal complication in advanced breast cancer patients, with the intricate brain microenvironment significantly limiting the efficacy of current therapeutic strategies. Recently, the neuro-astrocytic network, as a core component of the brain metastasis microenvironment, has garnered extensive attention for its pivotal role in supporting tumor adaptive growth. This review systematically outlines the adaptive mechanisms of the neuro-astrocytic network in BrM, including bidirectional interactions between tumor cells, neurons, and astrocytes, and their profound effects on synapse-like signaling, metabolic pathways, and regulatory networks. Furthermore, we integrate recent advancements in exploring therapeutic targets and discuss potential intervention strategies against tumor-microenvironment interactions and associated challenges. Future research focusing on the multi-target collaborative mechanisms within this network and its clinical translational potential may provide new avenues for precise treatment of BrM.