Identifying and visualising temporal trajectories of hospitalisations for traditional and non-traditional complications in people with type 2 diabetes: a population-based study

作者：Hongjiang Wu, Haobin Zhou, Chuiguo Huang, Aimin Yang, Eric S. H. Lau, Xinge Zhang, Juliana Nga Man Lui, Baoqi Fan, Mai Shi, Ronald C.W., Alice P.S. Kong, Elaine Chow, Wing Yee So, Juliana C.N. Chan, Andrea O. Y. Luk · 发表于：The Lancet Regional Health - Western Pacific · 年份：2025 · DOI：10.1016/j.lanwpc.2025.101532 · 被引用次数：2 · 研究领域：Chronic Disease Management Strategies、Primary Care and Health Outcomes、Diabetes Management and Education

Background: People with type 2 diabetes are increasingly susceptible to complications that are not specific to diabetes. We aimed to examine the temporal trajectories of hospitalisations for traditional and non-traditional complications in people with type 2 diabetes. Methods: We included 758,254 people with incident type 2 diabetes between 2002 and 2018 in Hong Kong, followed up until 2019. We included hospitalisations for 72 selected diseases and all-cause deaths. We derived the temporal trajectories of hospitalisations based on pairs of disease associations and identified trajectory clusters using Markov Cluster Algorithm. Findings: During a median follow-up of 7.8 (IQR: 4-12) years, 57.6% of people experienced a hospitalisation for any of the 72 selected diseases and 22.6% of people died. Among the 5184 directional disease pairs, 95 were identified as having a significant and directional association. The three most common disease pairs were hospitalisations for urinary tract infection followed by pneumonia, ischemic heart disease followed by heart failure, and ischemic stroke followed by pneumonia. Cardiovascular and kidney diseases were predominant in the hospitalisation trajectories. However, these traditional complications had complex associations both among themselves and with various non-traditional complications across multiple systems. Three distinct trajectory clusters were identified, with heart failure/chronic kidney disease, pneumonia, and urinary tract infecti...