A Nomogram for Diagnosing Ventilator-Associated Pneumonia Using Circulating Inflammation Indicators in ICU Patients

作者：Jiajia Yang, Weiyuan Bao, Hongmei Wang, Jie Zhou, Qiang Hu, Ying Wang, Y. Li · 发表于：Journal of Inflammation Research · 年份：2025 · DOI：10.2147/jir.s512083 · 被引用次数：7 · 研究领域：Nosocomial Infections in ICU、Inflammation biomarkers and pathways、Respiratory Support and Mechanisms

Purpose: To construct a risk nomogram model of ventilator-associated pneumonia (VAP) patients with mechanical ventilation in the intensive care unit (ICU) based on peripheral blood inflammatory indicators and to evaluate its diagnostic value. Patients and Methods: A matched 1:2 case: control study was conducted. Fifty-five mechanically ventilated patients with VAP and 113 patients without VAP were admitted to the ICU of Suzhou City Hospital with mechanical ventilation from January 2022 to June 2023 and were retrospectively included as study subjects. Clinical data and laboratory indicators of all patients were collected; the neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR), systemic immunoinflammatory index (SII), and systemic inflammatory response index (SIRI) were calculated, and endotracheal aspirate (ETA) culture results of VAP patients were recorded. Results: There were 61 pathogenic bacteria cultured in the ETA samples of 55 VAP patients, including 56 gram-negative bacilli, 4 gram-positive cocci, and 1 fungus. The proportions of hypoproteinemia, procalcitonin (PCT), NLR, PLR, SII, and SIRI in VAP patients were significantly higher than those in non-VAP patients, with statistical significance (P < 0.05). Univariate and multivariate logistic regression analyses showed that hypoproteinemia, PCT, NLR, PLR, and SIRI were independent influencing factors for VAP in ICU patients (P < 0.05). The ROC curve analysis resul...