Association of dietary inflammatory index on all-cause and cardiovascular mortality in U.S. adults with metabolic dysfunction associated steatotic liver disease

作者：Lin Tao, Tiantian Wu, Xiaoning Du, Qian Li, Yuefei Hao, Tao Zhou, Yinping Yi · 发表于：Frontiers in Nutrition · 年份：2025 · DOI：10.3389/fnut.2025.1478165 · 被引用次数：4 · 研究领域：Liver Disease Diagnosis and Treatment、Nutritional Studies and Diet、Gut microbiota and health

Backgrounds An inflammatory diet is pivotal in metabolic dysfunction-associated steatotic liver disease (MASLD) development. However, it remains unclear whether Dietary Inflammatory Index (DII), which serves as a reliable indicator to assess pro-inflammatory diet, have associative effects on mortality outcomes of MASLD. Methods Participants in the National Health and Nutrition Examination Survey (NHANES) database from 1999 to 2018 years were included. Kaplan–Meier (KM) curves were used to estimate survival probabilities, while Cox regression analysis and restricted cubic splines (RCS) were employed to assess the association between DII and mortality outcomes. The concordance index (C-index) evaluated the accuracy of multivariate-adjusted DII for mortality among MASLD participants. Results The cohort consisted of 4,510 men and 4,323 women with a median age of 52 years. Multivariate-adjusted Cox regression analysis revealed that high levels of DII were significantly associated with the all-cause mortality of participants with MASLD (multivariable-adjusted hazard ratio (aHR) = 1.28, 95% confidence interval (CI) 1.10–1.49, p = 0.002, DII aHR for cardiovascular mortality = 1.28, 95% CI 1.07–1.53, p = 0.006). The C-index for the multivariate model, integrating DII and other clinical variables, was 0.837 for all-cause mortality and 0.860 for cardiovascular mortality. RCS analysis showed a positive linear relationship between DII and all-cause mortality rate ( p for nonlinearity = 0....