Cross-Electrophile Coupling of Aryl Chlorides with Alkyl Chlorides Using Rotating Magnetic Field and Metal Rods

作者：Xiaomei Feng, Xiangye Li, Xiangye Li, Ning Zhang, Lizhi Zhang, Fenggang Sun, Hui Liu, Zengdian Zhao, Xinjin Li, Xinjin Li · 发表于：Journal of the American Chemical Society · 年份：2025 · DOI：10.1021/jacs.5c00381 · 被引用次数：16 · 研究领域：Catalytic Cross-Coupling Reactions、Fluorine in Organic Chemistry、Radical Photochemical Reactions

The pursuit of sustainable and environmentally benign methods and techniques continues to challenge organic chemists. Herein, we report the development of a novel approach in which electromagnetic induction could participate in the coupling of organic chlorides using a rotating magnetic field and metal rods. In particular, we describe the application of this strategy to the nickel-catalyzed cross-electrophile coupling of aryl chlorides with alkyl chlorides. Using these abundant and commercially available organochlorides, such a system allows reactions to proceed with a broader scope than the current protocols under mild conditions.